Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders
-
Published:2023-02-21
Issue:7
Volume:94
Page:560-566
-
ISSN:0022-3050
-
Container-title:Journal of Neurology, Neurosurgery & Psychiatry
-
language:en
-
Short-container-title:J Neurol Neurosurg Psychiatry
Author:
Oertel Frederike CosimaORCID, Zimmermann Hanna G, Motamedi Seyedamirhosein, Chien ClaudiaORCID, Aktas Orhan, Albrecht PhilippORCID, Ringelstein MariusORCID, Dcunha Anitha, Pandit LekhaORCID, Martinez-Lapiscina Elena HORCID, Sanchez-Dalmau Bernardo, Villoslada PabloORCID, Palace Jacqueline, Roca-Fernández AdrianaORCID, Leite Maria Isabel, Sharma Srilakshmi M, Leocani Letizia, Pisa Marco, Radaelli Marta, Lana-Peixoto Marco Aurélio, Fontenelle Mariana Andrade, Havla JoachimORCID, Ashtari Fereshteh, Kafieh Rahele, Dehghani Alireza, Pourazizi Mohsen, Marignier Romain, Cobo-Calvo Alvaro, Asgari Nasrin, Jacob Anu, Huda SaifORCID, Mao-Draayer Yang, Green Ari J, Kenney Rachel, Yeaman Michael R, Smith Terry J, Cook Lawrence, Brandt Alexander U, Paul Friedemann, Petzold AxelORCID
Abstract
BackgroundThe novel optic neuritis (ON) diagnostic criteria include intereye differences (IED) of optical coherence tomography (OCT) parameters. IED has proven valuable for ON diagnosis in multiple sclerosis but has not been evaluated in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders (AQP4+NMOSD). We evaluated the diagnostic accuracy of intereye absolute (IEAD) and percentage difference (IEPD) in AQP4+NMOSD after unilateral ON >6 months before OCT as compared with healthy controls (HC).MethodsTwenty-eight AQP4+NMOSD after unilateral ON (NMOSD-ON), 62 HC and 45 AQP4+NMOSD without ON history (NMOSD-NON) were recruited by 13 centres as part of the international Collaborative Retrospective Study on retinal OCT in Neuromyelitis Optica study. Mean thickness of peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (GCIPL) were quantified by Spectralis spectral domain OCT. Threshold values of the ON diagnostic criteria (pRNFL: IEAD 5 µm, IEPD 5%; GCIPL: IEAD: 4 µm, IEPD: 4%) were evaluated using receiver operating characteristics and area under the curve (AUC) metrics.ResultsThe discriminative power was high for NMOSD-ON versus HC for IEAD (pRNFL: AUC 0.95, specificity 82%, sensitivity 86%; GCIPL: AUC 0.93, specificity 98%, sensitivity 75%) and IEPD (pRNFL: AUC 0.96, specificity 87%, sensitivity 89%; GCIPL: AUC 0.94, specificity 96%, sensitivity 82%). The discriminative power was high/moderate for NMOSD-ON versus NMOSD-NON for IEAD (pRNFL: AUC 0.92, specificity 77%, sensitivity 86%; GCIP: AUC 0.87, specificity 85%, sensitivity 75%) and for IEPD (pRNFL: AUC 0.94, specificity 82%, sensitivity 89%; GCIP: AUC 0.88, specificity 82%, sensitivity 82%).ConclusionsResults support the validation of the IED metrics as OCT parameters of the novel diagnostic ON criteria in AQP4+NMOSD.
Funder
Guthy Jackson Charitable Foundation German Neurology Association Central Innovation Programme for SMEs of the German Federal Ministry for Economic Affairs and Climate Action
Subject
Psychiatry and Mental health,Neurology (clinical),Surgery
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|