1. Efficacy of low-dose methotrexate in rheumatoid arthritis;Weinblatt, M.E.; Coblyn, J.S.; Fox, D.A.; Fraser, P.A.; Holdsworth, D.E.; Glass, D.N.;N Engl J Med; sponse to corticosteroids supports an immune mediative phenomenon. The spontaneous remission during treatment,4 however,1985
2. Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A controlled clinical trial. Arthr reports that pulmonary toxicity may not recur after rechallenge remain to be explained.16 17 Rheum;Williams, H.J.; Willkens, R.F.; Samuelson, C.O.; Alarcon, G.S.; Guttadauria, N.; Yareoro, C.,1985
3. Methotrexate-induced pneumonitis. Medicine 1976; As methotrexate has been shown to 55: 371-88. accumulate preferentially in the lung, i8 and;Sostman, H.D.; Matthey, R.A.; Putman, C.E.; Walker-Smith, G.J.
4. Acute lung disease associated with low-dose clinical resolution may follow dose reduction,19 pulse methotrexate therapy in patients with rheumatoid it has been suggested that a direct cytotoxic action may be important in some instances.4 arthritis;Arthr Rheum,1983
5. Methotrexate pneumonitis after low-dose therapy for rheumatoid ar- Acute pulmonary toxicity appears, however, to be unrelated to either the dose or the duration of treatment. One important variable appears thritis;Engelbrecht, J.A.; Calhoon, S.L.; Scherrer, J.J.;Arthr Rheum,1983