Abstract
IntroductionChildren have a high consumption of antimicrobials that require complicated decision-making by prescribers. Despite this, antimicrobial stewardship (AMS) interventions are often not translated into paediatric medicine. Script is a smartphone application (app) launched in Auckland, New Zealand to support decision-making for antimicrobial prescribers. The aim was to improve adherence to existing local clinical guidelines for both adult and paediatric infections.MethodsInpatient and emergency department antimicrobial prescriptions were prospectively collected and evaluated for guideline adherence. Baseline prescribing data were collected and compared with prescribing at 4 months and 1 year after the app was launched. Prescriptions were graded as ‘appropriate’ or ‘inappropriate’ by investigators. Grading was done blinded to timing of the prescription relative to the intervention.ResultsFollowing the launch of the Script app, guideline adherence significantly increased from 241 of 348 (69%) antimicrobial prescriptions graded as appropriate during the baseline period to 301 of 359 (83%) after 4 months (p<0.0001). This improvement from baseline was sustained at 1 year with 263 of 323 (81%) adherence (p<0.001). At 1 year, this improvement could be demonstrated separately for medical, surgical and emergency department prescriptions.ConclusionThere was a significant and sustained improvement in adherence to paediatric antimicrobial guidelines following the introduction of a prescribing support app. The need to seek guidance for antimicrobial doses due to the age-based and weight-based calculations in paediatrics may mean that AMS interventions such as decision support and prescribing tools are particularly well suited to paediatric prescribing.
Funder
Joan Mary Reynolds Charitable Trust
Starship Foundation
Subject
Pediatrics, Perinatology and Child Health
Reference20 articles.
1. Antimicrobial Resistance Division, World Health Organisation . Global action plan on antimicrobial resistance; 2016.
2. The antibiotic resistance crisis: part 1: causes and threats;Ventola;P T,2015
3. Antibiotic consumption by New Zealand children: exposure is near universal by the age of 5 years
4. National Centre for Antimicrobial Stewardship A . National antimicrobial prescribing survey; 2016. Available: https://www.naps.org.au
5. The association between adherence to national antibiotic guidelines and mortality, readmission and length of stay in hospital Inpatients: results from a Norwegian multicentre, observational cohort study;Wathne;Antimicrob Resist Infect Control,2019