AB0240 CORRELATION BETWEEN KLOTHO LEVELS AND ANKLE-BRACHIAL INDEX IN FEMALE RHEUMATOID ARTHRITIS PATIENTS

Abstract

BackgroundRheumatoid arthritis (RA) that is a chronic systemic and disabling disease affecting 0.5–1% of the general population, have been strongly linked to accelerated aterosclerosis and increased incidence of cardiovascular events and mortality. Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs. The association between serum Klotho and the classic risk factors, as well as the clinical history of cardiovascular disease, was also shown. There are a lot of evidences that Klotho deficiency correlates with the occurrence and development of coronary artery disease, atherosclerosis, myocardial infarction, and left ventricular hypertrophy.ObjectivesThe aim of this study was to examine the possible association between serum Klotho levels and ankle-brachial index in women with RA.MethodsThis cross-sectional study was performed in Vega-Baja Hospital (Orihuela-Spain) from November 2016 to May 2018. We prospectively enrolled 63 consecutive female patients affected by RA and followed at the Vega-Baja Hospital (Orihuela-Spain). All patients included in this study had normal serum creatinine (Cr) levels and met the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for RA. Ankle-brachial index were evaluated using a BIDOP model ES-100V3 vascular screening system (Hadeco, Inc, Kawasaki, Japan). Serum Klotho (Elabscience, USA) was analysed using ELISA.ResultsOur study included 63 female patients, with a mean (SD) age of 53 ± 8 years. The majority were Caucasian (90.5%). The mean duration of RA was 8.5 ± 5.8 years. Mean 28-joint disease activity scores (DAS28) based on erythrocyte sedimentation rate (ESR) indicated low disease activity 3.0 ± 1.3. The mean of the health assessment questionnaire (HAQ) was 0.75 ± 0.67. Mean serum Klotho levels were 4.68 ± 1.14 ng/mL. The mean value of the ankle-brachial index was 1.14 ± 0.1.Lower serum Klotho levels were significantly associated with a lower ankle-brachial index (r 0.27, p<0.05).ConclusionDecreased serum Klotho levels are associated with peripheral arterial disease in women with RA.References[1]Kozera L, Andrews J, Morgan AW. Cardiovascular risk and rheumatoid arthritis—the next step: differentiating true soluble biomarkers of cardiovascular risk from surrogate measures of inflammation. Rheumatology. 2011; 50:1944-1954.[2]Hu MC, Shi M, Cho HJ, Adams-Huet B, Paek J, Hill K, et al. Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol. 2015; 26(6):1290–1302.[3]Olejnik A, Franczak A, Krzywonos-Zawadzka A, KaBuhna-Oleksy M, Bil-Lula I. The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases. Biomed Res Int. 2018; 2018:5171945.Disclosure of InterestsNone declared