AB0814 ASSOCIATION BETWEEN UVEITIS AND OTHER CLINICAL MANIFESTATIONS OF ANKYLOSING SPONDYLITIS

Abstract

BackgroundUveitis is a frequent extra-skeletal manifestation of ankylosing spondylitis (AS).Data on the association of uveitis with other clinical manifestations of AS are contradictory and require further study.ObjectivesTo assess the association of uveitis in AS with demographics and genetics, spine lesions, peripheral disease, coxitis, enthesitis.Methods402 AS pts (New York criteria, 1984), were observed in V.A. Nasonova Research Institute of Rheumatology. 168 pts had at least 1 episode of uveitis (group 1), 234 pts did not have uveitis (group 2). The patients underwent standard clinical, laboratory and instrumental examination, including HLA-27- testing, Х-ray examinaiton of joints and spine, ultrasonography of joints and entheses. Two groups were compared by gender, onset age and AS duration, presence of HLA-B27, damage of the spine, hip and peripheral joints and enthesitis.ResultsBoth groups were dominated by men: 117 of 168 in group 1 and 189 of 234 in group 2. However, among patients with uveitis, the proportion of women was significantly higher: 51/168 (30.3%) and 45/234 (19.2%), p=0.01. The average duration of the disease was comparable in both groups – 14.9±10.2 and 12.8±9.9 years, respectively. The number of patients with AS onset before the age of 16 also did not significantly differ: 22/168 (13.1%) in the group with uveitis, 35/234 (14.9%) in the group without uveitis, p=0.6. HLA-B27 in the group with uveitis was in 166/168 patients (98.8%) and in 221/234 (94.4%) in the group without uveitis, p=0.04. Syndesmophytes were observed in both groups with similar frequency: in the cervical spine - in 49/168 (29.1%) in group 1 and in 78/234 (33.3%) in group 2, p>0.05; in the lumbar spine – in 87 /168 (51.8%) and in 139/234 (59.4%), respectively, p>0.05. Hip joint lesion (coxitis) was present in 75/168 (44.6%) and in 112/234 (53.8%) respectively, p=0.52; enthesitis – in 114/168 (67,9%) and in 168/234(71,8%), p>0.05. Peripheral arthritis was observed significantly more often in the group with uveitis: in 113/168 (67.2%) and in 70/234 (33.2%) respectively, p<0.001; its predominant localization was knee - 71/113 (62.8%) and ankle - 54/113 (47.8%).ConclusionAS with uveitis is characterized by a greater proportion of women and stronger association with HLA-B27, compared with patients without uveitis. Peripheral arthritis with predominant involvement of the knee and ankle joints is significantly more common in AS pts with uveitis compared with pts without uveitis.References[1]Lee JH, Choi M, Rim THT, Lee SC, Lee CS. Clinical Characteristics and Prognostic Factors in Ankylosing Spondylitis Associated Uveitis.Ocul Immunol Inflamm. 2019;27(1):64-69. doi: 10.1080/09273948.2017.1359630.Disclosure of InterestsNone declared