POS1150 BONE MINERAL DENSITY AND TRABECULAR BONE SCORE IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Abstract

BackgroundPatients with systemic lupus erythematosus (SLE) have an increased risk of osteoporosis and low trauma fractures due to several important factors: the inflammatory disease itself, low vitamin D level, use of some disease-modifying anti-rheumatic drugs, glucocorticoids, etc. [1]. Bone mineral density (BMD) and trabecular bone score (TBS) measured by DXA are the important parameters of bone strength that evaluate the different aspects of bone architecture [1, 2].ObjectivesThe aim of the research was to determine BMD and TBS in women with SLE.MethodsWe have examined 150 females from 20 to 75 years old (average age – 51.1±11.6 years) which were divided into 2 groups: patients with SLE (n=50) and healthy women (n=100). The females did not differ in terms of age (51.4±10.8 and 50.4±13.2 years, respectively; p=0.60), height (163.8±15.4 and 163.6±6.6 cm, p=0.86), body mass (73.6±15.9 and 68.8±14.8 kg, p=0.09), and the duration of the postmenopausal period (8.9±6.9 and 9.6±8.1 years, p=0.81), but the age of menopause was significantly lower in patients with SLE (47.9±4.7 and 42.1±15.3 years, respectively, p<0.05). The BMD was measured at the lumbar spine, femoral neck, proximal femur, and total body, by means of the “Prodigy” unit (CE Medical systems, model 8743, 2005). The TBS was evaluated using the installed TBS iNsight software for an X-ray densitometer (Med-Imaps, Pessac, France).ResultsThe parameters of BMD were significantly lower in patients with SLE compared to the healthy women in all measured areas: in the total body (0.95±0.05 and 1.06±0.12 g/cm2, respectively; р=0.03), in the lumbar spine (0.87±0.13 and 0.96±0.17 g/cm2, р=0.02), femoral neck (0.68±0.11 and 0.75±0.14 g/cm2, р=0.03), proximal femur (0.83±0.10 and 0.92±0.16 g/cm2, р=0.02). In the patients with SLE TBS was significantly lower compared to the index in healthy women (1.28±0.11 and 1.33±0.12 un., р=0.02).ConclusionThe parameters of BMD and TBS in women with SLE are significantly lower than in the healthy population. Our results emphasize the importance of combined BMD and TBS measurement in the evaluation of the different aspects of bone architecture for dynamic monitoring of bone health and risk of fracture in patients with SLE and timely start of osteoporosis treatment.References[1]Bultink I.E.M. (2011). Osteoporosis and fractures in systemic lupus erythematosus. Arthritis Care & Research, 64(1), 2–8. doi:10.1002/acr.20568.[2]Ruaro B., Casabella A., Paolino S. et al.(2020). Trabecular Bone Score and Bone Quality in Systemic Lupus Erythematosus Patients. Frontiers in Medicine, 7. doi:10.3389/fmed.2020.574842.Disclosure of InterestsNone declared