AB0465 COMPARISON OF ULTRASOUND STRUCTURE CHANGES OF SALIVARY GLANDS IN PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME WITH POSITIVE AND NEGATIVE ANTICENTROMERE ANTIBODIES

Abstract

BackgroundApart from anti-Ro and/or anti-La positive primary Sjögren’s syndrome (pSS), there is a unique subtype of pSS with anticentromere antibodies (ACA). At the present time salivary gland ultrasonography (SGUS) is widely used to assess the structure of the salivary glands in pSS, but there are few publications about SGUS changes in ACA-positive patients [1].ObjectivesTo investigate SGUS changes in ACA (ACA+) positive pSS patients and compare with ACA-negative (ACA–).MethodsWe examined 141 patients with pSS, including 103 ACA– patients (pSS-ACA–) with the mean age 49,8 ± 14,1 years and 38 ACA+ positive (pSS-ACA+) with the mean age 59,1 ± 10,2 years. All patients underwent standard examination for the diagnosis of pSS (stomatological, ophthalmological, immunological), and SGUS performed using GE LOGIQ 9 of two parotid and two submandibular glands. Ultrasound images were evaluated with the OMERACT SGUS scoring system (SGUS SS) from grades 0 to 3 [2]. Statistical analyses (chi-squared test, p <0.05) were performed using STATISTICA version 12.ResultsCharacteristics of patients with pSS-ACA+ and pSS-ACA– are presented in Table 1.Table 1.ParametersACA–ACA+N%N%Oral dryness8683,53694,7Ocular dryness7673,83078,9Enlargement of parotid salivary glands3634,9718,4Recurrent parotitis2322,3760,5ANA ≥1:32010310038100Stimulated saliva flow test < 2.5 ml/5 min6563,13078,9Sialectasia on parotid sialography10310038100Stimulated Schirmer’s test <10 mm/5 min6765,02668,4Tear breakup time <10 seconds5957,32052,6Focus score ≥ 1foci/4 mm29491,312/1392,3MALT-lymphomas87,7513,1Characteristics of SGUS SS in pSS-ACA+ and pSS-ACA– are shown in Figure 1.Figure 1.We did not find significant differences when comparing SGUS SS in patients with pSS-ACA+ and pSS-ACA–.ConclusionWe did not find significant differences in SGUS and SGUS SS in patients with pSS-ACA+ and pSS-ACA–.ReferencesFURS-2022-003[1]Min HK, Kim SH, Park Y, et al. Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren’s syndrome. PLoS One. 2021;16(11):e0259519. Published 2021 Nov 3. doi:10.1371/journal.pone.0259519[2]Jousse-Joulin, Sandrine et al. “Video clip assessment of a salivary gland ultrasound scoring system in Sjögren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise.” Annals of the rheumatic diseases vol. 78,7 (2019): 967-973. https://doi:10.1136/annrheumdis-2019-215024Disclosure of InterestsNone declared