AB0874 FUNCTIONALITY IN OSTEOARTHRITIC GAIT IS RELATED TO TREATMENT DECISION. A MULTIFACTORIAL ANALYSIS

Abstract

Background:Osteoarthritis (OA) is a degenerative disease with complex underling mechanisms1–3. The interactions among several factors make the study of the disease very complex and often lead to different treatment, i.e. surgical or conservative, decisions for subjects clinically and radiographically similar. Recent explorations performed at the body level pointed out that macro-factors, like overweight or gait, can influence the development of the disease4. The number of related factors is high, and they are very likely to interact with each other. However, the literature lacks randomized and balanced studies to verify such effects of multiple factors5.Objectives:The aim of this work was to develop a multifactorial analysis to explore whether and how gait functionality and dynamics can be related to treatment decision.Methods:A multifactorial analysis of gait dynamics in OA subjects was developed. 81 OA subjects, graded 2-3 in KL, were selected based on 4 clinical factors: Gender (male – female), Age (60-67 – 68-75), BMI (25–29.9 – 30+) and Treatment (total knee replacement (TKR) – conservative treatment). Gait analysis was performed using 8 cameras BTS Smart-DX 700, 1.5 Mpixels 250 fps and 2 force plates BTS P-6000 500 Hz sampling (BTS S.p.A., Milan, Italy). Helen Hayes marker protocol with medial markers was used for the study. Each volunteer was asked to perform a minimum of 5 valid gait sequences. Functionality and dynamics parameters were measured.Functionality: Velocity of gait and the time needed to perform a gait cycle were computed.Dynamics:The reaction forces and torques at the ankles, knees and hips were computed through inverse dynamic analyses.Analysis of variance was performed for the four factors described among the functionality and dynamics parameters.Results:The multifactorial analysis showed that functionality values are more subjective to the studied factors than the dynamics ones.Functionalityseems to be directly related to the clinical treatment. Patients who selected TKR needed more time to make a step, spent more time in double stand position and walked slower (p<0.002). Older subject also walked slower but this dependency seemed to variate with age (interaction between clinical treatment and age – p<0.02 – Figure 1).Figure 1Interaction between Clinical treatment and age.Dynamics: Forces at the joints seemed to be affected by the gender and an interaction between age and BMI (p< p<0.005, p<0.02) but not by the kind of therapy. Differently, torques were statistically related to the clinical treatment (p<0.007). Age was also significant as was the interaction between age and BMI (both p<0.007).Conclusion:Reduced functionality seems to be related to the selection of therapy. In contrast to current paradigm, forces at the joints may have no role in the definition of the best therapy for OA subjects. Subjects requiring TKR do not present higher loads at the joints. However, torques seems to be related to the therapy selected. Instead of forces, kinematics and posture assessments might support rational definitions of the therapy and future multifactorial analysis should take them into consideration.References:[1]Ding M. et al.J Bone Joint Surg Br. 2003;85(6):906-912.[2]Kamibayashi L. et al.Calcif Tissue Int. 1995;57:69-73.[3]Li B, Aspden RM.J Bone Miner Res. 1997;12(4):641-651.[4]Berenbaum F et al.Curr Opin Rheumatol. 2013;25(1):114-118.[5]Ioannidis JPA.Soc Sci Med. 2018;210(April):53-56.Acknowledgments:MICINN Funds are acknowledged (HOLOA-DPI2016-80283-C2-1/2-R, RYC-2015-18888)Disclosure of Interests:None declared