Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate

Author:

Keystone Edward C,Taylor Peter C,Drescher Edit,Schlichting Douglas E,Beattie Scott D,Berclaz Pierre-Yves,Lee Chin H,Fidelus-Gort Rosanne K,Luchi Monica E,Rooney Terence P,Macias William L,Genovese Mark C

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference18 articles.

1. Jaks and STATs: biological implications;Leonard;Ann Rev Immunol,1998

2. Mechanisms of disease: JAKs and STATs in immunity, immunodeficiency, and cancer;O'Shea;N Engl J Med,2013

3. Janus kinase inhibitors in autoimmune diseases;O'Shea;Ann Rheum Dis,2013

4. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050;Fridman;J Immunol,2010

5. A randomized dose-ranging, placebo-controlled study of INCB028050, a selective JAK1 and JAK2 inhibitor in subjects with active rheumatoid arthritis [abstract];Greenwald;Arthritis Rheum,2010

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