The QT interval: a predictor of the plasma and myocardial concentrations of amiodarone.

Author:

Debbas N M,du Cailar C,Bexton R S,Demaille J G,Camm A J,Puech P

Publisher

BMJ

Subject

Cardiology and Cardiovascular Medicine

Reference17 articles.

1. The effect of amiodarone, a new anti-aninal drug, on cardiac muscle;Singh, B.N.; Vaughan Williams, E.M.,1970

2. A third class of antiarrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ1999 and AM3474;Singh, B.N.; Vaughan Williams, E.M.;BrJ Pharmacol,1970

3. Drugs with a class III antiarrhythmic action;Bexton, R.S.; Camm, A.J.;Pharmacol Ther,1982

4. Intravenous amiodarone: an effective antiarrhythmic agent;Curry, P.V.L.; Holt, P.; Way, B.; Awar, S.; Holt, D.;Br HeartJ,1982

5. excluded from the analysis. There were highly Campbell RWF. Amiodarone tissue distribution: relasignificant relations between the increase in this measurement and amiodarone dosage and between plasma and myocardial concentrations. The higher the dosage, the longer the QTc intervals. A threshold dosage of 0 96 mg/kg/day was necessary to produce a measurable increase in the QTc interval. It has been previously suggested that the increase in the QTc interval is directly related to the efficacy of the drug,8 tion to adverse effects;Adams, P.C.; Nicholson, M.R.; Storey, G.C.A.; Holt, D.W.,1983

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