Abstract
Clostridioides difficileis a micro-organism well known to cause pseudomembranous colitis with rare extraintestinal manifestations. We present the case of an elderly male with multiple comorbidities who presented with acute onset of fever/chills and hypotension, found to have polymicrobial bacteraemia withC. difficileandPseudomonas aeruginosa. He was treated with piperacillin/tazobactam forP. aeruginosabacteraemia, oral vancomycin forC. difficilecolitis and intravenous, followed by oral metronidazole forC. difficilebacteraemia.Pseudomonascleared after 1 day, andClostridioidescleared after 4 days. Following an initial septic presentation, he responded appropriately to antimicrobial therapy and did well in follow-up.