MetastaticHER2lacrimal/salivary gland duct adenocarcinoma

Abstract

In this report, we present a case of a patient with a 30-year history of orbital asymmetry who presented with metastatic human epidermal growth factor receptor 2 (HER2) positive lacrimal/salivary gland ductal adenocarcinoma. The patient was treated with chemoradiotherapy and trastuzumab. Tumours of lacrimal gland origin are rare, and unfortunately can frequently present in late stage. There are no current guidelines on the optimal treatment of metastatic lacrimal gland tumours, in particular those withHER2amplified malignancy. This case highlights a unique presentation of a rare disease, and the potential for targeted therapy.