Abstract
Anti-Yo paraneoplastic cerebellar degeneration (PCD) is a rare autoimmune neurological syndrome characterised by cerebellar symptoms and frequently associated with gynaecological malignancies. While typically preceding the diagnosis of the malignancy, rarely it may present later in the disease course, heralding a recurrence prior to biochemical or radiological confirmation. Disease management is challenging and prognosis remains poor.We present the case of a woman with stage IV ovarian adenocarcinoma who developed anti-Yo PCD 16 months post malignancy diagnosis while receiving bevacizumab maintenance therapy. We review the literature and outline the difficulties in diagnosis and the frequently refractory nature of PCD to available treatments.
Reference40 articles.
1. Aly R , Emmady P . Paraneoplastic cerebellar degeneration [statpearl]. ncbi.nlm.nih.gov. 2021. Available: https://www.ncbi.nlm.nih.gov/books/NBK560638
2. Dalmau J , Rosenfield M . Paraneoplastic cerebellar degeneration. uptodate.com. 2021. Available: https://www.uptodate.com/contents/paraneoplastic-cerebellar-degeneration
3. Paraneoplastic antigens as biomarkers for early diagnosis of ovarian cancer;Chatterjee;Gynecol Oncol Rep,2017
4. Paraneoplastic neurologic syndrome in ovarian carcinoma;Oughli;Gynecologic Oncology,2015
5. Paraneoplastic neurologic syndrome: a practical approach;Kannoth;Ann Indian Acad Neurol,2012