1. USED nique and studied circulation times extensively, The agents used have been 20 per cent sodium reporting their results in 1927 and 1928. Their dehydrocholate in 18 estimations of the arm-tongue method involved using radium C and was an objectime, and 50 per cent saccharin in a further 22 tive one, but owing to the technical complexity of estimations. Saccharin has been used owing to the the apparatus and agent it is unsuitable for clinical recent difficulty in obtaining decholin, although this work. Most of the methods described subsequently latter gives a sharper and more distinctive end point for the arm-tongue time have been subjective, and has a lower threshold concentration for taste;M.E.T.H.O.D.
2. 35 estimations of the arm-lung time, 5 per sodium cyanide. In 1933, sodium dehydrocholate cent paraldehyde in saline has been used. The was used in a series reported by Tarr, Oppenheimer, normal range for the arm-tongue time, using these and Sager, although its first use is credited to agents, is 11 to 17 seconds, and for the arm-lung;except those using fluorescein; histamine
3. Nebauer in 1923. Saccharin was introduced by time 3
4. With the Reports have appeared from time to time of unexception of Blumgart's radium method, measurepleasant effects from the use of decholin, and in ments of the arm-lung time depend upon a subjecthree cases these have resulted in the patients' death, tive reaction, and ether, introduced by Hitzig;Fishberg, Hitzig; in 1933, King
5. and paraldehyde first used by Caudel in 1938, showed a previous history of sensitivity, such as were the agents commonly used. An excellent asthma, etc.; if patients with such a history are review of the methods devised was published by excluded from injections, it seems that decholin is a Baer and Slipakoff in 1938