Effective Treatment of Chemotherapy with Anti-EGFR Antibody for an Unresectable Lynch Syndrome-associated Small Intestinal Cancer—A Case Report—

Author:

OYAMA Koki1,TOYOFUKU Atsushi2,KUBO Akihiro1,KOREEDA Yuki2,KATSUKI Takefumi2,YOTSUMOTO Shinji3,NAGATA Naoki2

Affiliation:

1. Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University

2. Department of Surgery, Kitakyushu General Hospital

3. Department of Radiology, Kitakyushu General Hospital

Publisher

Japan Surgical Association

Subject

General Engineering

Reference29 articles.

1. 1) 大腸癌研究会/編:遺伝性大腸癌診療ガイドライン 2016年版.東京,金原出版,2016,p39-81

2. 2) Lynch HT, Snyder CL, Shaw TG, et al : Milestones of Lynch syndrome : 1895-2015. Nat Rev Cancer 2015 ; 15 : 181-194

3. 3) Le DT, Uram JN, Wang H, et al : PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 2015 ; 372 : 2509-2520

4. 4) Le DT, Durham JN, Smith KN, et al : Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 2017 ; 357 : 409-413

5. 5) Overman MJ, McDermott R, Leach JL, et al : Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142) : an open-label, multicentre, phase 2 study. Lancet Oncol 2017 ; 18 : 1182-1191

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