Oksidatif stres paraoksonaz enzim ailesinin (PON) kanser üzerindeki etkisini arttırır mı? Pon ailesinin oksidatif stres ve kanser ilişkisinin incelenmesini amaçlayan bir derleme-Reference-Cited by-同舟云学术

Oksidatif stres paraoksonaz enzim ailesinin (PON) kanser üzerindeki etkisini arttırır mı? Pon ailesinin oksidatif stres ve kanser ilişkisinin incelenmesini amaçlayan bir derleme

Published:2022-11-10 Issue: Volume: Page:
ISSN:2146-409X
Container-title:Sakarya Medical Journal
language:tr
Short-container-title:

Author:

UYSAL Tugba Kevser¹,ÖRNEK Muhammet¹,ÖZENSOY GÜLER Özen¹

Affiliation:

1. ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOLOJİ ANABİLİM DALI

Abstract

Cancer development and progression are associated with oxidative stress. Oxidative stress can favor high concentrations of reactive oxygen species (ROS), and free radicals are associated with antioxidant metabolism. The human enzyme paraoxonase (PON) contributes to antioxidant metabolism and decreased antioxidant levels. This leads to a high-risk factor for coronary heart disease. This review focuses on specific changes that affect the DNA molecule, and signaling pathways, and regulate the various cancers through the attraction of PON, an enzyme for degrading lipid peroxides within the cell as well as lipoproteins in the bloodstream.

Publisher

Sakarya Tip Dergisi

Subject

General Computer Science

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