The content of leukocytes with sex chromatin in the blood and bone marrow of newborn mice

Abstract

In the colostrum period, in the formation of immunity in newborns, a significant role belongs to colostrum cells, namely, lymphocytes. The synthesis of colostrum by the mammary gland is an important component for the further growth and development of offspring. Lymphocytes, getting into the body of a newborn with colostrum, activate the system of cellular immunity. In newborns, leukocytes with Barr bodies are found in the blood and bone marrow and, therefore, are maternal leukocytes transferred to the newborn along with colostrum. Sex chromatin (or Barr's body) is found in the cells of females only. Given this fact, it was interesting for us to detect the presence of leukocytes with Barra bodies in the blood and red bone marrow of newborn male mice. The aim of our study was to identify the presence of leukocytes with sex chromatin in the blood and bone marrow of newborn mice. The blood and bone marrow of newborn male mice of the colostrum period were used for the study. Prepared blood and red bone marrow preparations were examined using immersion optics. The study of the leukogram showed that in 3-day-old male mice there is a change in the blood profile from neutrophilic to lymphocytic. The ratio of lymphocytes and segmented neutrophils was 62,44±1,73 % and 42,34±1,56 %, respectively. At the same time, sex chromatin was found in 4,13± 1,35 % lymphoid cells, while in the red bone marrow of newborn male mice, 13,26±1,84 % lymphocytes were cells of maternal origin (p<0,001). Lymphocytes with maternal sex chromosomes penetrate into the central organs of the immune system of the newborn male mouse. In the colostrum, the content of lymphoid cells in the secretion of the mammary gland increases. The transfer, with colostrum, of immunity from the mother to the newborn is not only passive, but also the foundation is laid for the normal functioning of the immune system in the future. Colostrum cells are the basis of colostral cellular immunity. As a result, the newborn establishes a stable and long-term immunity.