Role of the FABP gene family in the regulation of lipid metabolism of the common carp (Cyprinus carpio) breeding population

Abstract

The study of the genetic aspects of the regulation of lipid metabolism at the present stage is of particular importance. To develop a complete differentiated approach to assessing the initiation and progression of metabolic disorders, it is necessary to use molecular genetic markers that allow more accurate diagnosis and control the effectiveness of the treatment.The aim of our study was to study the role of the FABP family gene in the regulation of lipid metabolism in the brood stock of common carp (CYPRINUS CARPIO).The article presents the data on the expression of the FABP gene involved in the regulation of lipid metabolism. The study was conducted on one of the farms of Voronezh region specializing in the breeding and rearing of commercial fish. The studied breeding population was divided into two groups, according to the age indicator. The first group (n=6) (the main population) was formed by individuals weighing 4-7 kg, aged 4-7 years, the second (n=6) – individuals weighing 8-17 kg, aged 7 years and older. When studying the expression level of the FABP3 gene in the liver, which is involved in the β-oxidation of fatty acids, the following results were obtained: in the second group, its level was by 5.5 times higher than in the liver of individuals of the first group. The level of expression of the FABP3 gene in mucus in the two groups of fish did not differ statistically. When assessing the expression level of the FABP3 gene in the common carp (Cyprinus carpio) in the liver and mucus, in the group with aged individuals, the expression of the FABP3 gene was significantly higher than in younger individuals, which in our opinion may be associated with age-related disorders of the process of β-oxidation of fatty acids.