Investigation of metabolism and functioning of the antioxidant system in cats with tripelphosphate urolithiasis

Abstract

Urolithiasis  is  a  chronic  disease  of  the urinary  tract  of  a  polyethological  nature, accompanied  by  the  formation  of  uroliths and sand in the kidneys and urinary tract, as well as signs of dysuria, pollakiuria, ischuria,  urinary  colic,  periodic  hematuria  and crystalluria. The purpose of our research was to study the metabolism and functioning of the  antioxidant  system  in  cats  with  tripelphosphate  urolithiasis.  The  results  of  our study of the metabolism and antioxidant system  of  sick  animals  indicated  the  development of disorders of redox regulation of cells in tripelphosphate erythrolithiasis in cats. A disorder of liver functional activity was detected  (AST  -  41.74±5.35  Units/l  and 49.30±6.74  Units/L;  ALT  - Units/l  and  Units/L;  ALKP - Units/L and  Units/L; BILT -  mmol/l  and mmol/l; BILD -  mmol/l and 1.62mmol/L;  AAR  –  0.49±0.03  and 0.54±0.02) and violation of cell redox regulation  (MDA  -  1.29±0.08  nmol/ml  and 1.40±0.10  nmol/ml;  SOD -  265.90±12.08 Units/ml and 280.05±10.43 Units/ml; coenzyme  Q10  -  579.03±19.06  ng/ml  and 505.42±23.10  ng/ml;8-OHdG -  0.15±0.01 ng/ml  and  0.13±0.02ng/ml;  ascorbic  acid - 5.03±0.91  mcg/ml  and  4.70±1.03  micrograms/ml; TAS - 1.25±0.07 mmol/l and 1.23±0.05  mmol/L;  GTP -  6234.00±24.82 Units/g Hb and 6015.12±27.56units/g Hb) in cats with tripelphosphate urolithiasis. It was found that there is a direct close correlation between the level of liver transaminases and the activity of antioxidant enzymes, as well as  between  the  level  of  circulating  kidney biomarkers and the level of the main markers of oxidative stress in urolithiasis struvite type in cats, which allows us to expand the understanding of this disease and use these data  in  the  implementation  of  therapeutic measures.