Relationship of indicators of morphofunctional disorders of the hepatobiliary and gastrointestinal systems in dogs with chronic gastroduodenitis with malanutriation syndrome

Abstract

Malnutrition syndrome is widespread in veterinary gastroenterological practice, since most pathologies of the digestive system are accompanied by the development of maldigestion and malabsorption in the intestinal mucosa and the development of a disorder in the subsequent transport of nutrient substrates, detrimental to animal health.Studies have been conducted to study the relationship of the morphofunctional state of the hepatobiliary and gastrointestinal systems in dogs with chronic gastroduodenitis with malnutrition syndrome. Scientific research was carried out during 2022 at the Donskoy State Agrarian University and at the Bely Klyk veterinary clinic (Novocherkassk) as part of a project on scientific research topics included in the scientific work plans of scientific organizations and educational institutions of higher education that carry out scientific research at the expense of federal budget "Development of a comprehensive algorithm for diagnosing and correcting disorders of the hepatobiliary and gastrointestinal systems in dogs with malnutrition" (state registration number 122030200112-4). It was revealed that malnutrition syndrome is widespread in gastroduodenal pathology in dogs, causing weight loss, development of metabolic disorders and worsening the prognosis of the underlying disease. As a result of biochemical studies of the blood of sick animals with chronic gastroduodenitis with malnutrition syndrome, a disorder of proteinenergy and water-electrolyte metabolism, as well as liver dysfunction with the development of oxidative stress of hepatocytes, was established. The presence of a relationship between the level of morphofunctional disorders of the hepatobiliary and gastrointestinal systems in chronic gastroduodenitis in dogs, accompanied by a violation of the absorption and digestion of nutrient substrates in the intestinal mucosa, was revealed. The results obtained in the framework of this study increase the usefulness of the examination of animals and the validity of the clinical diagnosis, as well as form promising directions for the scientific search for more effective means of preventing and treating gastrointestinal diseases.