Affiliation:
1. FSBSI "All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy"
Abstract
The aim of the work is to study the effect of the complex drug interamin on the morphological blood indicators of calves with signs of antenatal hypotrophy. The object of the study were newborn calves, which were divided into 4 groups. The calves of the first experimental group (n=10, hypotrophic calves) were administered the complex drug interamin subcutaneously, five times on days 1, 3, 8-14, 18-24 and 56-60 of life at a dose of 1 ml per 10 kg of animal body weight. The calves of the second experimental group (n=10, hypotrophic calves) were administered "Biferon-B" subcutaneously, according to the above scheme. The calves of the third (n=10, negative control, hypotrophic calves) and fourth (n=10, control, normotrophic calves) groups were not treated with drugs. On the first day after birth, as well as on days 7, 30 of life and 5-10 days after the transfer to the rearing group, venous blood samples were taken from calves to assess its morphological composition. It has been established that hematological failures develop the calves with antenatal hypotrophy, manifested in the form of hypochromic anemia and a tendency to pancytopenia. The use of the drug interamin contributed to the activation of hematopoietic processes in calves with signs of antenatal hypotrophy. Thus, the number of erythrocytes in calves treated with interamin was significantly higher by 10.2, 7.6, 31.0% than in the calves from the negative control group, and the hemoglobin level from 7 to 60 days of life was within the reference range for these ages of this animal species. At the age of 7 days, against the background of the introduction of interamin, the number of leukocytes also increased by 6.4%, with a decrease in stab neutrophils by 52.5%, and segmented neutrophils – by 20.1%, with an increase in the percentage of lymphocytes by 39.4% relative to those in calves from the negative control group, and did not significantly differ from the indicators of normotrophic calves.
Publisher
Saint-Petersburg State University of Veterinary Medicine
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