Features of clearance of exogenous sorbitol in laboratory animals

Abstract

Clearance plays an important role in determining the functional activity of organs and systems that are directly involved in the metabolization and removal of various exogenous substances. It is also an important indicator for measuring the effect of xenobiotic dosage on their concentration in biological fluids over various time periods, which allows the use of these parameters for diagnostic purposes. However, methods for determining clearance are directly dependent on the removal characteristics of the substance. The purpose of this study is to conduct an experimental study aimed at establishing the clearance of exogenous sorbitol in laboratory animals with the absence of pathologies of the hepatobiliary and excretory systems. Having analyzed the data obtained, we concluded that clearance rates were stable after enteral administration of sorbitol in clinically healthy animals, i.e. with each time interval passed, the concentration of sorbitol decreases by a certain value. The clearance indicator was characterized by positive values, which indicates that exogenous sorbitol is not retained in biological fluids. The results of the study showed stable and comparable interindividual clearance rates, which indicates the linearity of the process of sorbitol elimination in the absence of pathologies. A positive feature of this reduction is its predictability and the possibility of using this information for clinical purposes. However, it should be noted that the linear decrease in the concentration of an exogenous substance may be disrupted in some cases, for example, in the presence of pathological conditions; therefore, a further direction of research will be to study changes in the pharmacokinetic parameters (in particular, clearance) of sorbitol in various pathologies of the hepatobiliary system.