OECD Chemicals Testing Regulation: validity for toxicological studies

Abstract

In order to validate the methods used to determine the toxicity of drugs, researchers usually turn to the most authoritative scientific literature, the system of state standards, or alternative systems. One of them is the OECD (Organization for Economic Co-operation and Development) regulations on testing chemicals. The article provides a brief analysis of the OECD regulations for testing chemicals (in particular, Chapter 2 “Effects on Biotic Systems” and Chapter 4 “Effects on Health”), which is a set of internationally recognized specifications for testing chemicals approved by the Organization for Economic Co-operation and development. The basic principles of conducting an experiment, the requirements for biological models for research, and the general system for assessing a particular type of toxicity were assessed. The main benefit of applying the OECD regulation in the context of toxicological studies is that it ensures uniformity of approaches and methodology in assessing chemical safety at the international level. This facilitates the comparison of research results, as well as the exchange of information between countries and organizations. Data quality control and adherence to GLP principles also provide confidence in research results, which is the basis for decision-making in chemical regulation and the protection of human, animal and environmental health. In general, OECD regulations in the context of toxicological research play an important role in ensuring safety and protecting public health and the environment. It provides standards and recommendations that facilitate the effective assessment of chemical safety and the development of appropriate measures to ensure it.