Affiliation:
1. Federal Center for Toxicological, Radiation and Biological Safety
Abstract
The review article presents the relevant results of comprehensive studies aimed at studying the toxins of Bacillus anthracis. The structural features of protective antigen, lethal and edematous factors are shown. The mechanism of translocation of a complex of toxins into the cytosol of the cell is presented. The orientation of the action of lethal and edema toxins on the cells of a susceptible organism and the mechanisms of their cytotoxicity are analyzed. The mechanisms of action of toxins in the early and systemic stages of infection are described. Issues have been identified regarding the interaction of toxins with target cells and their effects on various organs and tissues of the macroorganism, which require further in-depth studies.
Publisher
Saint-Petersburg State University of Veterinary Medicine
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