Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model

Author:

OBI-NAGATA Kisho1,TEMMA Yusuke1,HAYASHI-TAKAGI Akiko12

Affiliation:

1. Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University

2. PRESTO, Japan Science and Technology Agency

Publisher

Japan Academy

Subject

General Physics and Astronomy,General Agricultural and Biological Sciences,General Medicine

Reference112 articles.

1. 1) Birnbaum, R. and Weinberger, D.R. (2017) Genetic insights into the neurodevelopmental origins of schizophrenia. Nat. Rev. Neurosci. 18, 727–740.

2. 2) Sjostrom, P.J., Rancz, E.A., Roth, A. and Hausser, M. (2008) Dendritic excitability and synaptic plasticity. Physiol. Rev. 88, 769–840.

3. 3) Meyer-Lindenberg, A. and Weinberger, D.R. (2006) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 7, 818–827.

4. 4) Fino, E., Packer, A.M. and Yuste, R. (2013) The logic of inhibitory connectivity in the neocortex. Neuroscientist 19, 228–237.

5. 5) Yuste, R. (2011) Dendritic spines and distributed circuits. Neuron 71, 772–781.

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