Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane

Author:

TOTSUKA Yukari1,MAESAKO Yuya12,ONO Hanako3,NAGAI Momoko3,KATO Mamoru3,GI Min4,WANIBUCHI Hideki4,FUKUSHIMA Shoji56,SHIIZAKI Kazuhiro2,NAKAGAMA Hitoshi7

Affiliation:

1. Division of Carcinogenesis & Cancer Prevention, National Cancer Center Research Institute

2. Department of Life Sciences, Graduate School of Life Sciences, Toyo University

3. Department of Bioinformatics, National Cancer Center Research Institute

4. Department of Environmental Risk Assessment, Osaka City University, Graduate School of Medicine

5. Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety

6. Association for Promotion of Research on Risk Assessment

7. National Cancer Center

Publisher

Japan Academy

Subject

General Physics and Astronomy,General Agricultural and Biological Sciences,General Medicine

Reference24 articles.

1. 1) IARC (1999) 1,4-Dioxane, in: re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. IARC Monogr. Eval. Carcinog. Risks Hum. 7, 589–602.

2. 2) Agency for Toxic Substances and Disease Registry (ATSDR) (2012) Toxicological Profile for 1,4-Dioxane. ATSDR, Atlanta, GA.

3. 3) U.S. EPA (2013) United States Environmental Protection Agency, IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Final Report) (EPA/635/R-11/003F). https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0326tr.pdf.

4. 4) U.S. EPA (2017) United States Environmental Protection Agency, Technical Fact Sheet–1,4-Dioxane (EPA 505-F-17-011). https://www.epa.gov/sites/production/files/2014-03/documents/ffrro_factsheet_contaminant_14-dioxane_january2014_final.pdf.

5. 5) Kano, H., Umeda, Y., Kasai, T., Sasaki, T., Matsumoto, M., Yamazaki, K. (2009) Carcinogenicity studies of 1,4-dioxane administered in drinking-water to rats and mice for 2 years. Food Chem. Toxicol. 47, 2776–2784.

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