CORRECTION OF CYTOKINE AND HORMONAL IMBALANCE IN THE TREATMENT OF ANGINA PECTORIS

Abstract

Aim. To evaluate the dynamics of cytokine status (IL-1ß, IL-4, IL-6, IL-10) and hormonal profile (cortisol, ACTH, β-endorphins) in patients with stable angina II-III functional class in the course of standard treatment and combined use of TES-therapy.Materials and methods. All patients were divided into 2 groups: 1st (n=30) therapy of angina according to the Protocol and 2nd (n=30) combined therapy of angina according to the Protocol and TES-therapy.Results. The results showed that normalization of the studied cytokines level in patients of the 1st group is not improved.In the 2nd group of patients statistically the levels of the studied cytokines was significantly decreasing (p≤0.01) and the levels of ACTH, cortisol and β-endorphin were significantly (p≤0.01) increasing.Conclusion. The obtained results suggest that TES-therapy conducted in the 2nd group of patients, contributes to the correction of cytokine imbalance and hormonal profile, which indicates the necessity of its inclusion in standard therapy of angina.