PROSPECTS FOR THE DEVELOPMENT OF REGENERATIVE TECHNOLOGIES. CURRENT KNOWLEDGE OF PLATELET RICH PLASMA AND THE POSSIBILITY OF ITS APPLICATION IN TREATMENT OF COMPLICATED UROLOGICAL DESEASES

Abstract

Currently, the most actual problem in daily work of a surgeon is to get satisfactory results of the surgery, and to decrease the quantity of different complications, such as: recurrence of diseases, inflammatory and infection damage of operating wounds.The most difficult for surgery treatment are urological diseases associated with the decrease of tissue vascularization, which leads to common fibrosis and the prevalence of soft tissue scarring, consequences of the radiation therapy.Impaired wound healing is usually associated with lack of adequate blood supply, decrease of regenerative properties, increase of pro-inflammatory mechanisms. Platelet rich plasma is able to produce a lot of different growth factors, which stimulate neoangiogenesis, cytokines and сhemokines secretion, initialization of inflammatory cascade. These features lead to activation of regenerative mechanisms and growth of new blood vessels. In the present time, several forms of platelet rich plasma with different biological activity have been studied. The methods of its preparation and activation have been described. In this work the modern information of platelet rich plasma will be described in details.