INDICATORS OF OVARIAL RESERVE, PRO- AND ANTIOXIDANT SYSTEM, CYTOKINE STATUS OF PERIPHERAL BLOOD AND PERITONEAL LIQUID IN PATIENTS WITH ENDOMETRIOID OVARIAN CYSTS-Reference-Cited by-同舟云学术

INDICATORS OF OVARIAL RESERVE, PRO- AND ANTIOXIDANT SYSTEM, CYTOKINE STATUS OF PERIPHERAL BLOOD AND PERITONEAL LIQUID IN PATIENTS WITH ENDOMETRIOID OVARIAN CYSTS

Published:2019-03-13 Issue:1 Volume:26 Page:138-145
ISSN:2541-9544
Container-title:Kuban Scientific Medical Bulletin
language:
Short-container-title:Kuban. nauсh. med. vestnik

Author:

Sokolova Ekaterina I.¹,Kutsenko Irina I.²,Kravtsova Elena I.²,Batmen Saida K.²

Affiliation:

1. Hospital of the Kuban State Medical University, Ministry of Health of the Russian Federation

2. Kuban State Medical University, Ministry of Health of the Russian Federation

Abstract

The aimof this work was to identify the characteristics of the cytokine status and state of the pro- and antioxidant systems in patients of late reproductive age with endometrioid cysts and determine their role in changing the ovarian reserve.Materials and methods.A total of 89 patients with endometrioid ovarian cysts (EOC) were examined. The control group consisted of 35 healthy patients admitted for surgical sterilisation. Peripheral blood was collected before surgery, while the peritoneal fluid collection was performed intraoperatively. In peripheral blood and peritoneal fluid, the level of cytokines was determined. The calculation of the anti-inflammatory index was performed, along with the evaluation of the content of lipid peroxidation products and the antioxidant activity. The analysis of the ovarian reserve parameters was conducted.Results.In patients of late reproductive age suffering from EOC, a decrease in the ovarian reserve is observed under the preserved hormonal background. The presence of EOC is accompanied by the activation of lipid peroxidation, both at the systemic and local levels, under a pronounced inhibition of the antioxidant defence link. At the systemic and local levels, patients with EOC experience an imbalance in the cytokine system with a significant activation of the pro-inflammatory component.Conclusion.The disruption of oxidative homeostasis and activation of immune inflammation, detected in patients of late reproductive age with EOC, may lead to the damage of the structural cell components of the functional ovarian tissue, thereby reducing the ovarian reserve.Conflict of interest: the authors declare no conflict of interest.

Publisher

Kuban State Medical University

Subject

General Medicine

Reference9 articles.

1. Adamyan L.V., Martirosyan Yа.O., Asaturova A.V. Etiopathogenesis of endometriosis-associated infertility (a review). Problemy Reproduktsii. 2018; 24(2): 28–33 (In Russ., English abstract). DOI: 10.17116/ repro201824228-33

2. Kuzemenskaya M.L., Poddubnaya T.I. Endometriosis of ovaries as a cause of women’s infertility (review). Nauchnaya Diskussiya: Voprosy Mediciny. 2016; 5(36): 39–47 (In Russ., English abstract).

3. Pavlov R.V., Aksenenko V.A., Sel’kov S.A., Ailamazyan E.K. Features of cellular composition of peritonealny liquid and exchange of tsitokin at women with external genital endometriosis. Akusherstvo i Ginekologiya. 2009; 1: 36–40 (In Russ.).

4. Ermolova N.V. Value of violations of processes of cellular regulation in development of the broken genital endometriosis. Rossiiskii Vestnik Akushera-Ginekologa. 2008; 8(3): 33–36 (In Engl., Russ. abstract).

5. Ishchenko A.I., Zhumanova E.N., Ishchenko A.A. et al. New concepts of organsparing treatment for adenomyosis. Akusherstvo i Ginekologiya. 2013; 12: 86–91 (In Russ., English abstract).