Affiliation:
1. University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge, U.K.
Abstract
The oomycete Phytophthora palmivora infects a wide range of tropical crops worldwide. Like other filamentous plant pathogens, it secretes effectors to colonize plant tissues. Here, we characterize FIRE, an RXLR effector that contains a canonical mode I 14-3-3 phospho-sensor–binding motif that is conserved in effectors of several Phytophthora species. FIRE is phosphorylated in planta and interacts with multiple 14-3-3 proteins. Binding is sensitive to the R18 14-3-3 inhibitor. FIRE promotes plant susceptibility and co-localizes with its target around haustoria. This work uncovers a new type of oomycete effector target mechanism. It demonstrates that substrate mimicry for 14-3-3 proteins is a cross-kingdom effector strategy used by both prokaryotic and eukaryotic plant pathogens to suppress host immunity. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Funder
Gatsby Charitable Foundation
H2020 European Research Council
Royal Society
Sainsbury Laboratory School of the Biological Sciences Doctoral Training Program PhD Studentship supported by Gatsby and the University of Cambridge
Subject
Agronomy and Crop Science,General Medicine,Physiology
Cited by
5 articles.
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