Abstract
Objective. Complex estimation of state of the immune system tumoral chain in patients, suffering purulent cholangitis was done to determine diagnostic and prognostic immunological markers in different course of the disease.
Materials and methods. Depending on pathological changes in biliary system of the investigated patients, they were distributed into three groups: I –cholangitis, caused by choledocholithiasis, ІІ – cholangitis in environment of cicatricial strictures, ІІІ – cholangitis in environment of performed reconstruction of ductal system. The levels of immunoglobulins A, M, G, and cytotoxical tumoral factors were investigated.
Results. In acute course of inflammation the changes in immunoreactivity were determined, showing high levels of immunoglobulins of early immune response. In chronic cholangitis the enhanced raising of the blood serum cytotoxicity was noted, and its level connection with the disease clinical severity. Statistically significant high level of the middle molecular mass polypeptides have constituted the result of accumulation of secondary endogenic toxins with their insufficient elimination.
Conclusion. The summarized amplitude in the immunoreactivity changes was maximally pronounced in patients with an acute course of cholangitis, demonstrating high levels of the early immune response immunoglobulins. In chronic course the signs of the immune response exhaustion dominated.