Abstract
Objective. To study the character and peculiarities of pathohistological changes of pancreatic tissues on the autopsy material, including its endocrine apparatus in acute necrotic pancreatitis and to determine connection between established changes and occurrence of glycemia.
Materials and methods. Pathohistological investigation of 48 preparation of pancreatic gland was performed on the autopsy material in 11 dead patients with an acute necrotic pancreatitis, using method of the light microscopy.
Results. There was established the presence of microstructural disorder of pancreatic acinar apparatus with various degree of spread and depth of the organ parenchyma necrosis, as well as parapancreatic cellular tissue. With beginning of the false pancreatic cysts formation there was demonstrated occurrence of the connective tissue elements, as well as focal and diffuse sclerosing, while the structure of islets of Langerhans remained unchanged.
Conclusion. The signs of hyperglycemia in the disease course may be do not connected with destruction of the organ endocrine apparatus.