Abstract
Objective. To determine the dynamics of changes of mostly important cytokines in sepsis on background of destructive forms of erysipelas.
Materials and methods. There were examined 216 patients, suffering destructive forms of erysipelas, in 30 (13.9%) of them the disease was complicated by sepsis. All the patients were operated on. Postoperative lethality in group of patients with destructive forms of erysipelas without sepsis have constituted 1.1%, while with sepsis – 36.7%. The level of systemic cytokine, named the tumor necrosis factor α, proinflammatory cytokines – interleukins -1β, -6, -10, proinflammatory cytokine interleukin-2 have been determined dynamically: at the time of admission to hospital, on the 7th – 8th and 12th – 16th postoperative days.
Results. Dynamics of changes of content in the blood serum cytokines witness the dependence of their imbalance from the inflammatory process severity. The contents of these cytokines ratio reflects intensity of alternative-destructive and regenerative-restoration processes, as well as dynamics and progression of the disease.
Conclusion. The cytokines regulation disorders in patients with destructive forms of erysipelas and sepsis lead to development of severe immune changes – from dysfunction to imbalance and immunodepression. The inflammatory process severity is influenced by the cytokines imbalance in the blood.