Abstract
Objective. To estimate morphometric changes of the artificial bladder muscular wall, which was formatted of terminal ileum, in experiment in early and late postoperative periods.
Materials and methods. The investigation was conducted in the chronic experiment conditions on 22 mini-pigs, ageing from 16 to 19 mo. After performance of cystectomy to the animals the artificial bladder was formatted, using terminal ileum. In 3, 6 and 12 mo after the artificial bladder formation the animals were removed from the experiment.
Results. Studying of thickness of longitudinal and circular muscular layers of artificial bladder in mini-pigs in 2 mo have shown its statistically meaningful enhancement, comparing with control value in 2,14 - (643.7 ± 53.1) mcm and 3.36 - (1358.11 ± 86.60) mcm times, accordingly, and the common muscular layer thickness have enhanced in 2.84 times – (2001.81 ± 143.40) mcm, caused by its hypertrophy. In 6 mo more intense processes of muscular wall hypertrophy were seen in artificial bladder of experimental animals: the longitudinal muscular layer thickness have had statistically significantly enhanced in 3.61 times, while of a circular one – in 5.42 times, and of a common - in 4.65 times. In 12 mo after ileocystoplasty in muscular wall of artificial bladder a statistically significant enhancement of longitudinal layer thickness was noted, comparing with according index of intact animals in 5.52 times, while a circular one – in 5.58, and a common – in 5.13 times.
Conclusion. The main processes of the artificial bladder muscular wall hypertrophy occur during first 6 mo after its formation, especially intensively in period from 3 to 6 mo. In consequent six-month period a statistically significant enhancement of the longitudinal muscle layer thickness of artificial bladder in 0.91 times was noted, comparing with according index in previous 6 mo and the indices of the longitudinal and circular muscle layers thickness, which did not differ statistically with according results of experimental investigations in previous 6 mo. The urine reservoir, formatted of the ileum part, was not accustomed for performance of new functions, because in its wall evolution and transformation occurs in a version of hypertrophy in longitudinal and circular layers as a result of the intestinal tube denervation and the urine impact.