TENOFOVIR DISOPROXIL FUMARATE RELEASE FROM GLUTARALDEHYDE CROSS-LINKED CHITOSAN/Β-CYCLODEXTRIN HYDROGEL

Author:

Yaman Nuh1ORCID,Erdogan Sevil2ORCID,Taşdelen Betül3ORCID

Affiliation:

1. TRAKYA UNIVERSITY

2. TRAKYA ÜNİVERSİTESİ

3. Namık Kemal University

Abstract

In this study, chitosan was produced from crayfish Astacus leptodactylus, and then it was used to synthesize chitosan-graft-β-cyclodextrin (CS-g-β-CD) hydrogel. The produced chitosan (CS) and the sythesized CS-g-β-CD hydrogel were characterized using a Fourier Transform Infrared Spectroscopy (FTIR), Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). Tenofovir disoproxil fumarate (TDF) was used as a model to investigate the antiviral drug release properties of the CS-g-β-CD hydrogel. The synthesized hydrogel had an almost homogeneous pore structure and a high swelling capacity which increases depending on the amount of β-Cyclodextrin (β-CD). The drug-loaded CS-g-β-CD hydrogels was examined by XRD and 1H-NMR, and SEM analyses. Seventy-three percent of the TDF loaded on the synthesized hydrogels was released into phosphate-buffered saline (PBS) solution at 37 ºC. The drug release behavior of all prepared CS-g-β-CD hydrogels fitted the Korsmeyer-Peppas model. The addition of β-CD into the gel improved the swelling ability and TDF release of the CS-g-β-CD hydrogel system.

Funder

Trakya University Scientific Research Projects Unit

Publisher

Hacettepe University

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