EXPERIMENTAL STUDY OF N-(γ-AMINOBUTYRYL)-1-AZA-4,7,10,13-TETRAOXACYCLOPENTADECANE HYDROCHLORIDE ANALGESIC ACTIVITY IN PAIN SYNDROMES OF DIFFERENT ETIOLOGY

Author:

Voloshchuk N. I.1,Orlenko O. B.1,Petrushenko V. V.1,Basok S. S.2,Larionov V. B.2,Golovenko M. Ya.2

Affiliation:

1. National Pirogov Memorial Medical University

2. A.V. Bogatsky Physico-Chemical Institute

Publisher

Scientific Society Anatomists, Histologists, and Embryologists, Ukraine

Reference15 articles.

1. Bohatskyi OV, Lukianenko MH, Voronina TO, ta in. vynakhidnyky N-(γ-aminobutyryl)-1-aza-4,7,10,13-tetraoksatsyklopentadekan hidrokhloryd, shcho maye antyamnestychnu, antyhipoksychnu ta protysudomnu aktyvnist. Patent 7121 Ukraina, MKY S 07 D 273/01. 1995 Cher 30. [in Ukrainian]

2. Holovenko MIa. Rol pokhidnykh 1,4-benzodiazepinu ta sporidnenykh spoluk u vyvchenni morfofunktsionalnoyi orhanizatsiyi neiroretseptoriv HAMK (ohliad literatury). Farmakolohiya ta likarska toksykolohiya. 2020; 14(6): 375–388. doi: https://doi.org/10.33250/14.06.375. [in Ukrainian]

3. Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021 May 29;397(10289):2082–2097. doi: 10.1016/S0140-6736(21)00393-7.

4. Cook DC, Goldstein PA. Non-canonical Molecular Targets for Novel Analgesics: Intracellular Calcium and HCN Channels. Curr Neuropharmacol. 2021 Oct 1;19(11):1937–1951. doi: https://doi.org/10.2174/1570159X19666210119153047.

5. Domenichiello AF, Ramsden CE. The silent epidemic of chronic pain in older adults. Prog Neuro-psychopharmacol Biol Psychiatry. 2019 Jul 13;93: 284–290. doi: https://doi.org/10.1016/j.pnpbp.2019.04.006.

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