Application of Polymerase Chain Reaction to Detect Rearrangement of Immunoglobulin Heavy Chain Genes in Lymphoproliferative Disease

Author:

Khalil Salem H.12,Siegrist Karen1,Akhtar M.1

Affiliation:

1. From the Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

2. Address reprint requests and correspondence to Dr. Khalil: King Faisal Specialist Hospital and Research Centre, MBC 10, P.O. Box 3354, Riyadh, Saudi Arabia.

Publisher

King Faisal Specialist Hospital and Research Centre

Subject

General Medicine

Reference37 articles.

1. Somatic generation of antibody diversity;Tonegawa;Nature,1983

2. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions;Sanz;J Immunol,1991

3. The pattern of joining (JH) gene usage in the human IgH chain is established predominantly at the B precursor cell stage;Wasserman;J Immunol,1992

4. Detection of immunoglobulin gene rearrangement in B-cell neoplasms by polymerase chain reaction gene amplification;Deane;Leuk Lymphoma,1991

5. T-cell receptor and immunoglobulin gene rearrangement analysis as a laboratory aid in the diagnosis of human malignant lymphoproliferative disease;Dietzsch;Aust N Z J Med,1991

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