Polymorphism of the fibroblast growth factor 2 gene (FGF 2) in Holstein cattle in the conditions of the Republic of Tatarstan

Abstract

The basic fibroblast growth factor is a signaling protein encoded by the FGF2 gene. The FGF2 gene is expressed by the endometrium of cattle and is an important factor contributing to the preservation of pregnancy in ruminants, regulates the expression of interferon-? (IFNT), which is involved in the production of milk. The aim of the work is to identify the polymorphism of the FGF2 gene (SNP11646 A ? G substitution) in intron 1 in the Tatarstan population of Holstein cows. 270 Holstein dairy cows were genotyped by PCR-RFLP. As a result of identification, three genotypes were identified: AA – 19.6%, AG – 42.6 and GG – 37.8 %, and the observed distribution of alleles A – 0.409 and G – 0.591. The population is in genetic equilibrium balance, but there is a shift an increase towards heterozygosity of individuals.