Low-Dose Gamma-Radiation Inhibits Benzo[a]pyrene-Induced Lung Adenoma Development in A/J Mice-Reference-Cited by-同舟云学术

Low-Dose Gamma-Radiation Inhibits Benzo[a]pyrene-Induced Lung Adenoma Development in A/J Mice

Published:2012-10-01 Issue:4 Volume:10 Page:dose-response.1
ISSN:1559-3258
Container-title:Dose-Response
language:en
Short-container-title:Dose-Response

Author:

Bruce Veronica R.¹,Belinsky Steven A.²,Gott Katherine³,Liu Yushi⁴,March Thomas⁵,Scott Bobby⁶,Wilder Julie³

Affiliation:

1. University of New Mexico, Biomedical Sciences Graduate Program, Health Sciences Center, and Lovelace Respiratory Research Institute, Respiratory Immunology Program, Albuquerque, NM

2. Lovelace Respiratory Research Institute, Lung Cancer Program, Albuquerque, NM

3. Lovelace Respiratory Research Institute, Respiratory Immunology Program, Albuquerque, NM

4. Lovelace Respiratory Research Institute, Biostatistics, Albuquerque, NM

5. Consultant Veterinary Pathologist, Albuquerque, NM

6. Lovelace Respiratory Research Institute, Pathophysiology, Albuquerque, NM

Abstract

Low-dose ionizing radiation (LDR) may lead to suppression of smoking-related lung cancer. We examined the effects of a known cigarette smoke carcinogen Benzo[a]pyrene (B[a]P) alone or in combination with fractionated low-dose gamma radiation (60 – 600 mGy total dose) on the induction of lung neoplasms in the A/J mouse. Our results show that 600 mGy of gamma radiation delivered in six biweekly fractions of 100 mGy starting 1 month after B[a]P injection significantly inhibits the development of lung adenomas per animal induced by B[a]P. Our data also indicated that the six biweekly doses suppressed the occurrence of spontaneous hyperplastic foci in the lung, although this suppression failed to reach statistical significance when analyzed as average foci per lung possibly related to the small sample sizes used for the control and test groups.

Publisher

SAGE Publications

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.2203/dose-response.12-040.Bruce

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