Quality by Design for Ciprofloxacin Encapsulation in PLGA Factors assessment followed by screening and optimization
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Published:2018-07-15
Issue:6
Volume:69
Page:1332-1338
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ISSN:0034-7752
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Container-title:Revista de Chimie
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language:en
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Short-container-title:Rev. Chim.
Author:
Mocanu Andreea Gabriela,Stiolica Adina Turcu,Belu Ionela,Ciocilteu Maria Viorica,Manda Valentin Costel,Nicolicescu Claudiu,Neamtu Johny
Abstract
The objective of this study is to formulate and characterize ciprofloxacin-PLGA nanoparticles in laboratory. Ciprofloxacin-PLGA nanoparticles were obtained with Ciprofloxacin and PLGA as raw materials at the room temperature. The optimum set of process parameters were determined using Design of Experiments (DoE) with the factors: PLGA concentration, Ciprofloxacin concentration, Agitation Rate and the responses: Particles Size, Ciprofloxacin Encapsulation. The optimized formulation had 36.83% Ciprofloxacin Encapsulation and 87.58nm Particles Size in the conditions of 10% PLGA Concentration, 24.8 mg Ciprofloxacin Concentration and 1500 Rpm.
Publisher
Revista de Chimie SRL
Subject
General Chemistry,Materials Science (miscellaneous),Materials Chemistry,Process Chemistry and Technology,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Pharmacology, Toxicology and Pharmaceutics
Cited by
2 articles.
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