Manganese and Zinc Overdose - Risk of Oxidative Stress Appearance

Abstract

The study presents the effect of Zn and Mn overdoses in relation with other trace metals in rat�s liver. All studied metals are involved in some enzymes activity, which are implicated in antioxidant defense system of the body. But, in some conditions � our case in overdoses � an imbalance can appear, and antioxidant character of a metal can become prooxidant. In this case, antagonistic or synergic behaviour in relation with other trace metals is obvious. The observed modifications are the increasing of zinc and manganese level in liver after solutions administration, and the amplification effect over the hepatic iron, with the possibility of oxidative stress appearance.