Research on Obtaining Nanostructured Surfaces Efficient in Combating Microbial Biofilm

Abstract

Infections that occur after the insertion of biomedical devices are a major problem; potential sources of infection are due to the adhesion of bacteria on the surface of implants, bacteria that form biofilms. In order to combat or to effectively prevent various microbial, which occur in medical procedures, we try to make compounds and materials that prevent the formation or development of microbial biofilm. The aim of this study was to obtain nanostructured surfaces based on magnetite, carboxymethylcellulose and ceftriaxone, as films with anti-infective properties in order to use them in the field of current biomedicine. To obtain nanostructured surfaces with high non-stick potential, the carboxymethylcellulose-functionalized magnetite powder was homogenized with an anti-infective agent, ceftriaxone. From the analysis of the obtained results it was found that the nanostructured surfaces obtained had a strong antimicrobial character infections and can be used successfully in the coating of medical implants, in order to combat the microbial biofilm.