Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate
-
Published:2021-04-05
Issue:1
Volume:58
Page:210-217
-
ISSN:0025-5289
-
Container-title:Materiale Plastice
-
language:en
-
Short-container-title:Mater. Plast.
Author:
Marin Aurel,Marin Maria Alina,Ene Ioan,Poenaru Marioara
Abstract
The current study was proposed in order to obtain, to characterize by usually physico-chemical methods and to assess in vitro, the potential cytotoxic effect of polyurethane microstructures loaded with epigallocatechin gallate (PU_MS) on human pharyngeal carcinoma cells (Detroit 562) and squamous cell carcinoma (SCC-4). The results showed that polyurethane microstructures obtained are stable and have dimensions that make them biocompatible with the biological environment. The cytotoxicity of test samples is dependent on concentration and 72 hours after stimulation at the highest concentration tested the viability of tumor cells was below 50%, the decrease being much more pronounced in the case of squamous cell carcinoma. The novel nanostructures loaded with epigallocatechin gallate induced an augmented cytotoxic effect, suggesting that this drug carriers are suitable to enhance the antitumor effect of epigallocatechin gallate.
Publisher
Revista de Chimie SRL
Subject
Materials Chemistry,Polymers and Plastics,Mechanics of Materials,General Chemistry
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献