Author:
Iftode Andrada,Racoviceanu Roxana,Susan Razvan,Marti Daniela,Pinzaru Iulia,Lazau Radu,Susan Monica,Gheorghisor Alexandra,Soica Codruta,Trandafirescu Cristina
Abstract
Fluconazole is a bistriazole derivative with antifungal activity. The major weak points of fluconazole are the development of antifungal resistance and low water solubility, which impairs its administration. Binary systems between fluconazole and beta-cyclodextrin were prepared with the aim of obtaining a new delivery system that will overcome the limitations of fluconazole administration. Using two feasible laboratory methods, inclusion complexes between fluconazole and beta-cyclodextrin were obtained. Thermal and spectroscopic analyses were used to characterize the inclusion complexes.
Subject
General Chemistry,Materials Science (miscellaneous),Materials Chemistry,Process Chemistry and Technology,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Pharmacology, Toxicology and Pharmaceutics
Cited by
5 articles.
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