Preparation of Dendritic Mesoporous Silica Nanomaterials Loaded with Toosendanin-Fumaracetin and its Anti-Peripheral Pain Study

Abstract

 Objective: A novel dendritic mesoporous silica nanomaterials (DMSN) was prepared and the traditional Chinese Medicine Component "Toosendanin-Tetrahydropalmatine"  was loaded  into  DMSN in order to improve the solubility  of Tetrahydropalmatine B, reduce the toxicity of Toosendanin, and enhance the anti-peripheral pain effect of the traditional. Chinese Medicine "Toosendanin-Tetrahydropalmatine" through preliminary pharmacodynamics study. Methods: DMSN were prepared using the sol-gel method and characterized by scanning electron microscope (SEM) and Fourier Transform Infrared Spectrometer (FT-IR). The preliminary study of the anti-peripheral pain pharmacodynamics of the drug-loaded system in mice was evaluated by the hot plate method. Results: The prepared DMSN has an excellent spherical shape in SEM, the size distribution of the DMSN is about 200nm, the size distribution is uniform, and the dispersion is good. The infrared results showed that the synthesized DMSN had organic functional groups and chemical structures. Compared with the control group, the pain threshold of DMSN loaded with the Toosendanin-tetrahydropalmatine group was prolonged by 45 seconds. Conclusion: The synthesized DMSN loaded with Toosendanin and Tetrahydropalmatine could release stably and continuously and had the effect of extending the pain threshold of mice. Therefore, DMSN drug delivery system has potential value in improving the bioabsorption of dangerous drugs and enhancing the bioavailability of poorly soluble drugs.