Abstract
The Notch pathway (NP) controls the growth and development of organisms through intercellular interactions, and is highly conserved. NP extensively affects human life activities. It has an involvement in a range of cellular processes, including the process of the differentiation and proliferation. For example, the normal development of neuronal cells, germ cells and sensory cells in living organisms depends on Notch-mediated inhibition of differentiation. Neurological growth, organ formation, immune system and tumorigenesis are also dependent on NP. Furthermore, available studies show that NP is critical not only in tumorigenesis and progression, but also in prognosis. Currently, the NP has become a hotspot for research in several fields. This article describes some of the roles played by the NP in the nervous system, organogenesis, and immune system. Some of the research advances in tumors related to NP are collated, and the research on the impact of interventions targeting Notch pathway on cancer treatment is summarized.
Publisher
Darcy & Roy Press Co. Ltd.
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