Recent Blood and Intracranial Molecular Biomarkers to Moderate Depression and Major Depressive Disorder

Abstract

Depression, especially moderate depression and MDD, brings huge pressure and loss to patients and society through a series of symptoms. However, the current diagnosis of depression is short of objective, quantifiable, and absolute detection techniques. If we can find specific depression molecular biomarkers and high-sensitivity and high-accuracy molecular biomarker detection technology, it can help patients with depression to diagnose and predict earlier. In this paper, the heterogeneous biomolecules of depression are classified into intracranial markers and blood markers, and the biomolecules with representative value are listed. Meanwhile, it analyzes and compares the current popular biological detection technologies, IHC and RNAscope. If the heterogeneous depression biomarkers can be detected by the combination of IHC and RNAscope technology, the accuracy and timeliness of depression diagnosis will be greatly improved, and lay the groundwork for better depression treatments in the future.