The Investigation of LPA Binding Sites on LPA 1 And LPA 4-Reference-Cited by-同舟云学术

The Investigation of LPA Binding Sites on LPA 1 And LPA 4

Published:2023-04-18 Issue: Volume:45 Page:151-159
ISSN:2791-0210
Container-title:Highlights in Science, Engineering and Technology
language:
Short-container-title:HSET

Author:

Zhang Huyang,Hou Wenjuan

Abstract

Lysophosphatidic acid (LPA) is a class of biologically active lipid molecules with important biological functions. LPA can induce various cellular responses through six LPA receptors (LPA1-6) on cell membranes to achieve its biological functions. This study utilized computer simulation tools such as AutoDock Vina and RosettaFold to investigate the binding sites of LPA1 and LPA4 to LPA molecules. Based on these results, this study could provide new insights for the subsequent development of extracellular antagonists and agonists, and facilitate drug formation for the treatment of cancer invasion.

Publisher

Darcy & Roy Press Co. Ltd.

Reference23 articles.

1. World Health Organization. (n.d.). Cancer. World Health Organization. Retrieved September 10, 2022, from https://www.who.int/news-room/fact-sheets/detail/cancer

2. Types of cancer treatment. National Cancer Institute. (n.d.). Retrieved September 10, 2022, from https://www.cancer.gov/about-cancer/treatment/types

3. July 28, 2022, June 29, 2022, & June 23, 2022. (n.d.). Overcoming the challenges of metastatic cancer. National Cancer Institute. Retrieved September 10, 2022, from https://www.cancer.gov/news-events/cancer-currents-blog/2017/metastatic-cancer-kaplan

4. Ahmad, M. U., Ali, S. M., Ahmad, A., Sheikh, S., & Ahmad, I. (2015). Lysophospholipids: Advances in synthesis and biological significance. Polar Lipids, 349–389. https://doi.org/10.1016/b978-1-63067-044-3.50015-7

5. Geraldo, L. H., Spohr, T. C., Amaral, R. F., Fonseca, A. C., Garcia, C., Mendes, F. de, Freitas, C., dosSantos, M. F., & Lima, F. R. (2021). Role of lysophosphatidic acid and its receptors in health and disease: Novel therapeutic strategies. Signal Transduction and Targeted Therapy, 6(1). https://doi.org/10.1038/s41392-020-00367-5