Inflammation In Relation to Alzheimer’s Disease and Potential Treatments

Abstract

Alzheimer's disease (AD) affected millions of people. As it is widely associated with its two hallmarks, Aβ and NFT, its relationship with inflammation is less studied, but gaining more attention in recent years as more experiments and researches provide sufficient results to prove the close relationship between the two. By collecting and covering a variety of experiments and reports conducted over the years, this review projects to include an in-depth analysis of pathogenesis of Alzheimer’s disease, discussing its connection with inflammation in its formation and development, while seeking for treatments targeting inflammation as a potential solution to prevent, reduce and reverse Alzheimer’s disease in the future. From researches done up to date, there are numerous failures regarding anti-inflammatory treatment of Alzheimer’s, but some early studies show positive results of new drugs targeting different inflammatory mechanisms which are able to attenuate the disease. More of relevant studies can be done in the future as a potential solution to AD.