CAR T-cell Therapy for Neuroblastoma

Abstract

Children aged under 5 being the main patient group of neuroblastoma has been widely acknowledged according to clinical diagnosis results. Traditional therapies like monoclonal therapy and chemo therapy have achieved relatively high curing rate, the 5-year survival rate of these therapies are still not acceptable, followed by strong side effects to microenvironment.  To help improve the prognosis of patients who have high risk and lift the survival rate, CAR T-cell therapy for neuroblastoma can be an achievable option. In this review, I summarize the mechanism of CAR T cell therapy, the general information about neuroblastoma and the current clinical experiences advancement in this area.